We further elucidated that the downstream signalling pathway correlated with RBBP5 tumor suppressor gene function in melanoma and verified that RBBP5-mediated tumor inhibition could be, at least partly, due to inhibition of Wnt/β-catenin signalling, which activation is important for T-cell exclusion, resistance to antiPD-L1/antiCTLA4 therapy, and progression of melanoma [26, 44, 45]. The gene discussed is RBBP5; the disease is melanoma.