In our study (Figures 2(a)–2(h)), we verified that the expression of RBBP5 was downregulated in melanoma tumor tissues and melanoma cells; furthermore, in our IHC results, the IHC score of positive RBBP5 staining in melanoma tumors was lower than the IHC score in adjacent tissues and nevi tissues. Here, RBBP5 is linked to neoplasm.