In addition to public databases, 33 paired GC tissues from Jiangsu Cancer Hospital (Nanjing, China) were collected to further confirm the expression of METTL3 and METTL14, all tissues were from patients who had been diagnosed pathologically as new cases of primary GC without radiotherapy, and RT-qPCR results of our tissues showed that METTL3 was significantly overexpressed, and METTL14 was significantly decreased (Figure 2(d)). This evidence concerns the gene METTL3 and cancer.