Several studies have used the mdx dystrophin deficient mouse, the most used animal model of the destructive human dystrophin deficient muscular dystrophy DMD, to study the chronic effects of oral administration of NAC in drinking water or by intraperitoneal injection on skeletal muscle pathology (Terrill et al., 2012; Pinto et al., 2013; Pinniger et al., 2017). Here, DMD is linked to Duchenne muscular dystrophy.