Located within the tandem repeat domain, this particular mutation has not been previously reported in CRC and is worth exploring its functional relevance in future studies.The MUC16 gene encodes for a highly glycosylated protein that consists of two primary domains: a tandem repeat domain (interspersed with SEA domain) containing the CA-125 epitope and a transmembrane domain (Hattrup and Gendler, 2008; Felder et al., 2014). This evidence concerns the gene MUC16 and colorectal carcinoma.