KDM4 proteins family consist of four paralogues, namely KDM4A- KDM4D, and two pseudogenes, KDM4E and KDM4F. While KDM4A and KDM4B are the widely-studied members of the KDM4 subfamily, the roles of KDM4E in cancers have rarely been reported (Wang et al., 2022a). This evidence concerns the gene KDM4E and cancer.