Some researchers have proposed a phenotypic continuum for the autosomal dominant diseases caused by ATP1A3 mutations, encompassing alternating hemiplegia of children (AHC), rapid-onset dystonia-parkinsonism (RDP), relapsing encephalopathy with cerebellar ataxia (RECA), cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorineural hearing loss (CAPOS), and developmental and epileptic encephalopathies (DEE) (Rosewich et al., 2014; Dard et al., 2015; Paciorkowski et al., 2015). The gene discussed is ATP1A3; the disease is aceruloplasminemia.