To ascertain whether these frequent variations play significant roles in the susceptibility to generalized genetic epilepsies, Qu et al. (2015) screened 484 patients with GGE and 284 healthy controls for eight tagSNPs in ATP1A2 and ATP1A3. According to the authors' hypothesis, frequent variations of ATP1A3 increase one's risk of developing GGEs. This evidence concerns the gene ATP1A3 and genetic generalized epilepsy.