ATP1A3 and status epilepticus: The answers to why ATP1A3 mutations resulted in poor responses to current AEDs may be attributed to that when the ATP1A3 mutations are placed in their proper context, a possible chain of events may be envisioned: some people are predisposed to status epilepticus (SE) because of pathogenic ATP1A3 gene variants; SE may increase the risk of recurrent seizures; and damage the mesial temporal lobe in a way that reduces GABA-mediated inhibition or misdirects regeneration, leading to a novel recurrent excitatory circuit (Sills, 2007).