The beginning of related studies can be traced back to the 2000s, and various early explorations have indicated the important roles of ATP1A3 in epileptogenesis and epilepsy, and have tried to elucidate the precise mechanisms (Li and Stys, 2001; Chu et al., 2009; Clapcote et al., 2009), although most of which were theoretical speculation. Here, ATP1A3 is linked to epilepsy.