KATP channels (activity altered by ATP1A3 malfunction) are thought to be responsible for the beneficial effects of ketosis on epilepsy (ref), which makes sense that dysfunction of the Na+/K+-ATPase caused by ATP1A3 mutation, which induces hyperexcitability in neurons, would also occasionally lead to inhibition of KATP channels (Tanner et al., 2011). Here, ATP1A3 is linked to epilepsy.