REN and type 2 diabetes mellitus: Although the three agonists had disparate targets, we intended to explore some shared targets for intervention in the progression of T2DM and MI, and 12 common targets were identified (Figure 3B), namely, AGTR1, AGTR2, CASP1, CCNA2, CCND1, CXCR4, EDNRA, F7, MME, REN, SCN5A, and SIRT1, suggesting that these 12 targets may contribute to the fundamental mechanisms of GLP-1RAs against T2DM and MI.