Among all reports referring to osteomyelitis, 405 cases referred to insulin and its analogs and generated an ROR of 1.32 (95% CI 1.08–1.62) and an IC025 of 0.09, which could be considered as a weak signal, and 484 cases referred to non-insulin hypoglycemic drugs other than SGLT2is and could not generate valid ROR (0.28) and IC025 (−2.25) values, which meant no signal. Here, INS is linked to osteomyelitis.