CASP3 and glioblastoma: It is a source of polysaccharides, flavonoids, terpenoids, tannins, alkaloids, enzymes, proteins, and vitamins (Musthafa et al., 2021) demonstrated the apoptotic potential of A. esculentus lectins against human glioblastoma cells by the modulation of the caspase-3 and caspase-7 gene expression and the downregulation of CLOCK and Bma1 circadian genes, implicating a correlation between these circadian genes and apoptotic cell death.