P2RX3 and glioblastoma: yunnanensis extract contained seven main active ingredients: Dioscin, Polyphyllin H, Polyphyllin I, Polyphyllin V, Polyphyllin VI, and Polyphyllin F. In glioblastoma or glial cells, little or no P2X3 receptors were expressed since P2X3 is specific for sensory neurons (Inoue and Tsuda, 2021).