It can exhibit a synergistic anti-liver cancer effect by increasing the expression of cleaved PARP, p-JNK, p-p38, and decreasing the expression of Bcl-2, Bcl-xL, CDK2/4/6, p-ERK, p38, via inducing generation of ROS and influencing MAPK signaling pathway, thereby inhibiting the proliferation and metastasis and inducing apoptosis of SMMC-7721 and Hep3B cells (181). The gene discussed is MAPK14; the disease is liver cancer.