JAK3 and cancer: In the murine lineage, APC and Brca2 are tumor suppressors, Apob gene is related to Apobec1, an RNA editing enzyme used to fend off RNA retroviruses from evolutionary perspective; CD44 is a cancer stem cell marker; KMT2C’s function remains unclear but its mutation is frequently found in cancers; Jak3 is part of Jak/STAT axis and is involved in cytokine signaling of immunity; and Yap1 is an oncogenic co-activator in Hippo pathway.