Also, Adegbola et al. demonstrated that the ginger extract at a dose of 500 mg/kg alone or in combination with Allium sativum 1000 mg/kg significantly declines the inflammation following the high-fat diet-induced obesity in rats by decreasing the IL-6 and TNF-α levels and lipid profile [49]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.