TNF and atherosclerosis: KEGG enrichment analysis revealed that the targets were mainly enriched in the AGE-RAGE signaling pathway in diabetic complications, lipids, and atherosclerosis, the HIF-1 signaling pathway, the PI3K-Akt signaling pathway, the TNF signaling pathway, the IL-17 signaling pathway, etc. Among the predicted key compounds, quercetin was the most promising target.