Moreover, in vivo experimental results confirmed that XHYTF may reduce renal fibrosis and inflammatory infiltration in rats with UAN, release of proinflammatory cytokines (TNF-α and IL-1β) and uric acid levels, and play a role in improving renal function through the targeted regulation of the PI3k/Akt pathway, which verified the accuracy of our analysis. The gene discussed is TNF; the disease is renal fibrosis.