CDK2 and prostate cancer: CDKs are key regulators of the cell cycle,107 and the proper regulation of CDK activity is crucial for the ordered execution of the cell cycle.108 CDK2/cyclin E expression abnormalities have been seen in colorectal, ovarian, breast, and prostate cancers.109 CDK2 is involved in many stages of the cell cycle, including DNA repair, gene transcription, the G1-S transition, and G2 progression modulation.110–112