We collected lung adenocarcinoma transcriptional profiling data and corresponding clinical information from the GDC, TISCH2 and GEO databases, explored the level of immune cell activation in lung adenocarcinoma by obtaining differential genes at the expression level, constructed a prognostic model for lung adenocarcinoma based on IL-1-associated genes, and identified several IL-1-associated key genes as potential biomarkers. Here, IL1B is linked to lung adenocarcinoma.