The interaction between inflammatory macrophages and β-cells promote the production of CXCR2 ligands (CXCL1 and CXCL2) in the pancreas of T1D mice, which further recruit diabetogenic CXCR2+ neutrophils from the blood into the pancreatic islets (187). Here, CXCR2 is linked to type 1 diabetes mellitus.