Various research about spontaneous T1D animal models has shown that specific clearance of macrophages in vivo can significantly inhibit Th1 but increase Th2 immune response induced mainly by IL-12, and inhibited cytotoxic effector of CD8+ T, even remaining selective acceleration of the recruitment of CD8+ T cells into the islets (177–179). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.