In addition, EGFR-dependent chromatin condensation, namely mitotic-like concentrated chromatin (MLCC), can protect KRAS-mutant NSCLC cells from ionizing radiation (IR)-induced DSBs and premature senescence (110), and enhance the expression of CSC marker protein CD133 via osteopontin/EGFR pathway, promoting tumor invasion and radioresistance (112). This evidence concerns the gene PROM1 and non-small cell lung carcinoma.