Mutant KEAP1 lost its inhibitory effect on NRF2 in cytoplasm, the activated NRF2 translocated to the nucleus and activated the expression of antioxidant proteins by binding to antioxidant-responsive elements (AREs), resulting in the scavenging of ROS and anti-apoptosis of tumor cells, leading to unlimited proliferation, metastasis and radioresistance of NSCLC (114–116). This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.