The expression of TP53-regulated inhibitor of apoptosis 1 (TRIAP1) in NSCLC cell lines A549 and H460 increased after irradiation, and caused upregulation of antioxidant proteins such as thioredoxin-related transmembrane protein (TMX) 1, TMX2, thioredoxin (TXN), glutaredoxin (GLRX) 2, GLRX3, peroxiredoxin (PRDX) 3, PRDX4 and PRDX6, participated in redox metabolism and enhanced the ROS scavenging, leading to radioresistance in NSCLC (79). The gene discussed is PRDX4; the disease is non-small cell lung carcinoma.