Besides, heat shock protein 90 (HSP90) (41), acidic nucleoplasmic DNA binding protein1 (AND-1) (42), sirtuin 3 (Sirt 3) (43), IQ motif containing GTPase-activating protein 3 (IQGAP3) (44), and serine proteinase inhibitor clade E member 2 (SERPINE2) (45) can enhance radioresistance via activating ATM to activate the HR pathway in NSCLC. The gene discussed is IQGAP3; the disease is non-small cell lung carcinoma.