For instance, the expression of bridging integrator 2 (BIN2), CCR5, and macrophage mannose receptor1 (MRC1) increased, and the expression of spleen tyrosine kinase (SYK) and metalloproteinase 12 (ADAM12) decreased in endometriosis tissues compared to non-endometriosis tissues (164). This evidence concerns the gene ADAM12 and endometriosis.