Additionally, Sema3A is an axon-repulsive guidance factor for neurons, and Sema3A/NRP-1 signaling recruits macrophages to the hypoxic microenvironment, such as the peritoneal cavity of endometriosis, and polarize macrophages from the M1 phenotype toward the M2 phenotype (55). The gene discussed is SEMA3A; the disease is endometriosis.