A study based on a hepatocellular carcinoma model demonstrated that CKLF1 regulates the tumor microenvironment by binding to CCR4 to initiate the IL-6/JAK/STAT3 signaling pathway, upregulating STAT3-related cytokines such as TNF-α and IL-17A, and inducing the expression of cell cycle regulatory genes including BCL-XL and cyclinsD1. The gene discussed is CKLF; the disease is neoplasm.