miR-130b and miR-32 in exosomes can stimulate the potential of the body’s autoimmune system, regulate phosphatase (PTEN) deletion on human chromosome 10, improve the transformation speed of M2 macrophages by PI3K/Akt signal transduction, and create a shortcut for glioma growth and migration (8).Several clinical trials have confirmed that hypoxic glioma-derived exosomes can promote glioma proliferation and migration (9). The gene discussed is PIK3CA; the disease is central nervous system cancer.