In tumor microenvironment, TREM2 expressed on TAMs is also directly involved in FOXP3 Treg cells recruitment and T CD8+ suppression, and Colonna et al., reported that anti-TREM2 mAB treatment could reduce the infiltration of immunosuppressive macrophages and expand the presence of cells expressing immunostimulatory molecules (36) (37) (38). The gene discussed is TREM2; the disease is neoplasm.