Prior murine studies showed the adoptive transfer of peripheral senescent CD8+ T cells (CD8+ CD44+ CD153+) from spleens of mice on a high-fat chow diet to mice on a normal chow diet was followed by insulin resistance in the recipient animals, suggesting a role for circulating T cells in the development of metabolic dysregulation (44). The gene discussed is TNFSF8; the disease is Insulin resistance.