UMAP visualization demonstrated that high expression of TNFR2 was presented in tumor-infiltrating Tregs and exhausted CD8 T cells across human breast cancer (BRCA), hepatocellular carcinoma (HCC), lung cancer (LC), and melanoma (MELA) (Figures 1G, H). The gene discussed is TNFRSF1B; the disease is invasive breast carcinoma.