Because mucosal infection induces a general inflammatory response that includes stimulation of IgA-secreting cells and Gd-IgA1 production and because desialylation of IgA is the natural catabolism of IgA, the postulated contribution of infection-mediated desialylation of Gd-IgA1 to disease activity in IgAN should be tested in future studies. The gene discussed is CD79A; the disease is infection.