In this study, our prognostic signature can further stratify PCa patients into subgroups with different immune infiltrations which indicated that numerous immune cells, such as the M1 phenotype of macrophages, NK cell resting, dendritic cell resting, T cell CD4 memory resting, and B cell naïve, were significantly higher in the high-risk group than that in the low-risk group. This evidence concerns the gene CD4 and posterior cortical atrophy.