6 of the 44 FGFs with high expression (PIK3CA, GRB2, SOS1, NRAS, BRAF, and MAPK3) in PCa patients were found to be associated with PCa BCR in comparison to its low expression (P = 0.0048, P = 0.0245, P = 0.0022, P = 0.0059, P = 0.0245, and P = 0.0145, respectively, Figure 3), and then, we choose two hub FRGs (SOS1 and PIK3CA) to validate by TMA analysis and construct a risk signature of PCa patients. This evidence concerns the gene MAPK3 and posterior cortical atrophy.