Second, although we found the signatures including SOS1 and PIK3CA play different roles in the FGF-related signaling process through other important cancer-related signaling pathways and immunotherapy-related NK cells for PCa patients, some basic experiments should be explored further, such as the biological functions and the specific mechanism of SOS1 and PIK3CA overexpression both in vivo and in vitro. The gene discussed is PIK3CA; the disease is cancer.