To verify the relationship of TIM-3, TNF-α, or IFN-γ protein expression with the clinicopathologic parameters of LAUD, gender, age, TNM stages, lymph node metastasis, smoke, CEA, BMI, location, tumor size, and date of operation were investigated in this study (Tables 1, –3). This evidence concerns the gene HAVCR2 and metastatic malignant neoplasm in the lymph nodes.