Inhibitor caspases, such as caspases 8, 9, and 10 must bind to a specific oligomeric adaptor protein, whereas effecter caspases i.e. caspases 3, 7, and 6, are stimulated using the active initiator caspase through proteolytic cleavage as well as degradation of a variety of intracellular proteins to promote apoptosis (Fig. 3) [127] explores the apoptosis mechanisms linked to cancer and phytoconstituents. The gene discussed is CASP8; the disease is cancer.