For example, the expression of miR-126 is up-regulated in asthma models, and the expression of POU domain type 2 binding factor 1 (OBF.1 or BOB.1) is up-regulated after miR-126 is blocked, which can inhibit the expression of transcription factor GATA3 by activating transcription factor PU1, inhibiting Th2 type response [49]. Here, POU2AF1 is linked to asthma.