CTLA4 and asthma: Recent studies have also shown that lncRNA-MEG3 can "sponge" adsorb miR-17 in CD4+ T cells of asthmatic patients, thereby regulating the expression of RORγt and ultimately affecting the balance of Treg/Th17, MALAT1 regulates the expression of CTLA-4 by adsorbing miR-155 through the "sponge" to participate in the regulation of Th1/Th2 balance in CD4+ T cells, suggesting that lncRNA/miRNA may have potential application value in the clinical treatment and diagnosis of asthma [12,89].