Second, cisplatin, one of the oldest and most widely used cancer chemotherapeutic (Alhadeff et al., 2017), also induces nausea and vomiting via Ca2+-dependent release of multiple neurotransmitters (including serotonin (5-HT), substance P (SP), dopamine, etc.) from both central emetic loci in the dorsal vagal complex (DVC) of the brainstem as well as peripherally in the GIT (Hesketh, 2008; Darmani and Ray, 2009). This evidence concerns the gene TAC1 and cancer.