Among the enriched pathways are neurotransmitter associated pathways (including dopamine synapse, serotonin synapse, oxytocin, adrenergic signaling, endocannabinoid signaling and GABA/Glutaminergic signaling), memory related pathways (such as long term potentiation, long term depression, and axon guidance) as well as neurobiology pathways associated with alcohol and amphetamine addiction. This evidence concerns the gene OXT and depressive symptom measurement.