The protective effect of UFH/LMWH could be attributed to reducing the inflammatory response, such as NF-κB/MAPK dependent secretion of TNF-α and IL-6, and dampening endothelial and epithelial cell damage to protect against sepsis-induced kidney and lung injury (Figure 4B) (Wang et al., 2015; Wang et al., 2020). The gene discussed is TNF; the disease is Sepsis.