For further investigations, it is appropriate to focus on probable effect of GSH-PMAA-EDV on enzymatic antioxidant activity and the expression of neurotrophic factors and inflammatory genes like TNF and NLRP-2 to get a more generalized idea of how drug delivery could affect the function of edaravone in counteracting ischemic stroke in both biochemically and genetically impairment. Here, TNF is linked to ischemic stroke.