We found that patients with HS had dramatically decreased frequencies of natural killer (NK) cells, dendritic cells (DCs), and classical (CD14 + CD16-; C.monos) and nonclassical (CD14-CD16+; NC.monos) monocytes, as well as significantly increased frequencies of Th17 cells and intermediate (CD14 + CD16+; I.monos) monocytes. The gene discussed is CD14; the disease is histiocytic sarcoma.