CXCR3 and multiple sclerosis: CXCR3 is one of the six CXC chemokine receptors and is highly expressed on different types of leukocytes, including CD4+ type-1 helper T cells (Th1), natural killer (Nk) cells, and monocytes under inflammation and infection conditions.[4] In fact, the upregulation of CXCR3 and its chemokines has been found in a variety of inflammatory diseases such as multiple sclerosis, arthritis, and atherosclerosis.[5] CXCR3 inhibition is emerging as a promising therapeutic strategy for inflammatory disorders.[5]