We collected structural brain MRI and cognitive-behavioral data from 40 pre-pubertal children with Noonan syndrome (NS), caused by <i>PTPN11</i> ( <i>n</i>  = 30) or <i>SOS1</i> ( <i>n</i>  = 10) variants (age 8.53 ± 2.15, 25 females), and compared them to 40 age- and sex-matched typically developing controls (9.24 ± 1.62, 27 females). This evidence concerns the gene PTPN11 and Noonan syndrome.