APOBEC3B and hepatocellular carcinoma: In agreement with this, all disseminated lymphoproliferative lesions also show strong A3B nuclear-only immunostaining (Figures 4I and S6), which differs from our prior studies in which human A3A protein expression is selected against and disappears in early stages of HCC development.15 No metastases were observed in the WT mice over the same time frame.