Three genes remained significant when we combined all epilepsy subtypes (Fig. 1a): DEPDC5 (log[OR]=2.1, P=3.4×10−15), NEXMIF (log[OR]=4.1, P=6.3×10−9), and SCN1A (log[OR]=2.7, P=3.5×10−8). The gene discussed is NEXMIF; the disease is epilepsy.