DEPDC5 and epilepsy: Notably, DEPDC5 was the only exome-wide significant hit in the earlier Epi4K WES study of familial NAFE cases;8 the expanded inclusion of non-familial cases in our cohort implicates DEPDC5 in both familial and non-familial cases (Supplementary Data 2), reinforcing the notion that sporadic and familial forms of epilepsy have shared genetic risk.