FLT3 and acute myeloid leukemia: CG-806 also upregulated the pro-apoptotic protein Bim in FLT3 WT and ITD mutant AML cell lines after 24 h of treatment, and later triggered the cleavage of caspase-3 and PARP in FLT3-ITD-mutated AML cells (Fig. 2C, Supplementary Fig. S2).