An AML model was established by intravenously xenografting GFP-tagged Ba/F3-FLT3-ITD cells (0.5 × 106 cells/mouse), infected with lentivirus expressing firefly luciferase, into NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice (eight-week-old female) (The Jackson Laboratory, Bar Harbor, ME). The gene discussed is FLT3; the disease is acute myeloid leukemia.