Immunoblot analyses demonstrated that CG-806 at nanomolar concentrations markedly suppressed phosphorylation levels of FLT3, AURK, and BTK, and their downstream signaling partners p-AKT and p-ERK in the leukemia cell lines and primary AML samples harboring FLT3-ITD mutations and/or FLT3-TKD mutations (Fig. 2A, B). This evidence concerns the gene AKT1 and acute myeloid leukemia.