Treatment with extremely low doses (nanomolar to sub-nanomolar) of CG-806 for 72 h profoundly inhibited cell growth via apoptosis induction in both human and murine leukemia cell lines harboring either FLT3-ITD mutations or FLT3-ITD+TKD point mutations (Fig. 1A, B). The gene discussed is FLT3; the disease is leukemia.