BCR-ABL oncoprotein interacts with other cytoplasmic proteins to activate the Ras-extracellular signal-regulated kinase (Ras-ERK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), PI3K-Akt, and signal transducer and activator of transcription 5 (STAT5) that lead to proliferation and resistance to apoptosis in cancer cells (4). This evidence concerns the gene ABL1 and cancer.