This study considered college students in Zhejiang as the research subject and screened out the genes by searching the relevant literature in NCBI PubMed; we screened the genes and SNP loci that might be associated with high myopia and finally identified rs939658, rs4778879, and rs8033417 loci on RASGRF1 gene, and analyzed their relationship with the susceptibility to high myopia of college students in this region. Here, RASGRF1 is linked to myopia.