RASGRF1 and myopia: Various gene sequence-mediated signaling pathways have been found to be involved in the development of myopia, among which genetic variants at the RASGRF1 locus have been associated with visual function and several of its SNP loci may be closely associated with high myopia [13], but analysis of the correlation between RASGRF1 gene polymorphisms and susceptibility to high myopia has been less frequently reported.