RASGRF1 and myopia: However, no evidence was found in the study of Fernandez-Medarde and Santos [19] to support the association of high myopia with the rs8033417 locus of the RASGRF1 gene, and analysis of the reasons for this may be related to the different single nucleotide polymorphism loci selected in this study, and differences in the inclusion criteria for high myopia can also cause changes in gene frequency [20].