In this study, the genotype frequency and allele frequency of SNP rs939658 and rs4778879 of the RASGRF1 gene between the myopia group and the control group were not significantly different, but the genotype frequencies and allele frequencies of the rs8033417 locus of the RASGRF1 gene were significantly different between the two groups, in which the risk of high myopia was significantly higher in C allele carriers than in T allele carriers, indicating that the C allele of the rs8033417 locus was associated with myopia. Here, RASGRF1 is linked to myopia.