ALB and focal dermal hypoplasia: To date, several albumin gene (ALB) variants, namely, p.Arg218His (R218H), p.Arg218Pro (R218P), p.Arg218Ser (R218S), p.Arg222Ile (R222I), and p.Leu66Pro (L66P) have been reported in FDH patients (1), of which the R218H variant, with an increased affinity for thyroxine (T4), was first described by Sunthornthepvarakul et al.