In the previous reports, all the three women reported with KASH5 mutations, which abolished the nuclear envelope distribution of the LINC complex, presented typical POI phenotype at their 20s or early 30s, including FSH levels higher than 40 mIU/mL, oligomenorrhea that ceased at 27, 31, and 23 years old, respectively, and small ovaries without visible follicles (16, 18). Here, BRD2 is linked to Oligomenorrhea.