Furthermore, we found that YTHDF2 deletion rescued the decrease in JAK1 levels caused by ALKBH5 knockdown in GC cells (Figure S4b).We have blocked YTHDF2 in the proliferation, invasion and migration of ALKBH5 knockdown cells in vitro and found that YTHDF2 deletion rescued the decrease in ALKBH5 knockdown‐mediated function in GC (Figure S4c–e).Taken together, our findings indicated that ALKBH5‐mediated m6A modification influenced JAK1 mRNA stability in a YTHDF2‐dependent manner. Here, JAK1 is linked to gastric cancer.