Overall, IFI16 is highly relevant to human health well beyond its role in defense against a wide variety of pathogens (9,12,13,24,25,28), as its dysregulation is associated with multiple autoimmune disorders (e.g. Sjögren's syndrome, systemic lupus erythematosus (SLE), and scleroderma (13,25,26,29)) and even cancer (e.g. breast, cervical and melanoma (30–33)). The gene discussed is IFI16; the disease is systemic lupus erythematosus.