Autosomal dominant gain-of-function mutations in LRRK2 result in the most common form of familial Parkinson’s disease.87LRRK2 encodes a large protein of 2527 amino acids and is known to have roles in autophagy, endocytosis and various protein interactions.87 Evidence suggests Parkinson’s disease-related LRRK2 mutations lead to DA release defects. Here, LRRK2 is linked to Parkinson disease.