PARK7 and Parkinson disease: Further to this list, both complete DJ-1 knockout as well as Parkinson’s disease-related DJ-1 mutations disrupt SV endocytosis.136 Substantial evidence supports that defective SV recycling and decreased reuptake of DA leading to lack of SV replenishment could be an important contributing factor to disruption of DA release in Parkinson’s disease (Fig. 2).