The broad and beneficial activity of TGR5 makes it a potential therapeutic target, and INT-777 and INT-767, for example, are two agonists of TGR5 that correct bile secretion and cell survival in patients with PBC.27,122 And INT-767 has been pointed out to reduce BAs synthesis, increase bicarbonate excretion and down-regulate NF-κB signaling.101. The gene discussed is GPBAR1; the disease is primary biliary cholangitis.