NR1H4 and cholestasis: Therefore, if the drug is well tolerated, side effects such as pruritus during treatment can be alleviated by starting OCA at the lowest recommended dose of 5 mg/day and increasing it to 10 mg/day after three months.6 Apart from OCA, other FXR agonists (LJN-452101, GS-9674102, EDP-305103) are emerging as potential therapeutics for cholestasis.