Mutations in these two genes have not been reported in FCD type I. MAP2K1 and PTPN11 are essential components of the RAS/MAPK pathway, which partially activates the mTOR pathway by phosphorylating ERK in the RAS/MAPK pathway and suppressing the TSC2 function [6, 29]. This evidence concerns the gene MTOR and isolated focal cortical dysplasia type I.