CD274 and non-small cell lung carcinoma: This has been attributed to particularly high levels of GM-CSF production [20], a high degree of mutational intertumoral and intratumoral heterogeneity [21], most KRASG12D-driven NSCLC tumours presenting in more “immune cold” never-smokers [22], and potentially, lower PD-L1 expression in KRASG12D tumours [16].