KRAS and neoplasm: This may be due to the reduced Foxp3 expression seen in STK11LOF/KRASWT tumours which impairs the function of Tregs [67], as well as the increased TMB and neoantigen load seen in both STK11LOF and KEAP1LOF tumours driven from aberrant ROS generation [68] and a lack of the KRAS-dependent MHC complex downregulation [34], which would enhance the effect of ICB (Fig. 1).