APOBEC3B and neoplasm: Interestingly, expression of human APOBEC3B in KrasLSL−G12D/+/Trp53fl/fl/RosaA3Bi mice with Rag2−/− (KPAR) background failed to produce a TMB/neoantigen-high tumour, but a clonal line from the resulting tumour gave rise to an immunogenic model with MHC-I presentation of the retroviral antigen Emv2; a common tumour antigen in other immunogenic lines (CT26, B16, MC38) [102], as well as human breast cancer and melanoma [103].