DNASE1 and COVID-19: In accordance observed in the COVID-19 model, isolated NETs from the culture of PMA-stimulated human neutrophils induced in vitro apoptosis of A549 epithelial cells with reversal homeostasis in presence of DNase I. A549 is a great tool for mimicking the lung inflammatory environment and was used as a model to investigate NET-induced apoptosis of lung cells, as stated above.