TNNI3 and neoplasm: Unique to our study is the finding that the incidence of low-level hs-cTnI changes was as high as 6.6% in this cohort of East Asia colorectal cancer patients irrespective of whether they received radiotherapy and chemotherapy prior to tumor resection surgery and are independently associated with change in risk of MACE, Jia and colleagues suggested that elevated hs-TnI is strongly associated with increased global CVD incidence in white or African American [28], but notable racial and ethnic differences and disparities exist in CVD epidemiology and outcomes [30].