Subsequently, the 72 hypermethylated genes in t(8;21) AML from the DMR7 profile were aligned with the 986 downregulated genes in t(8;21) AML from TCGA, resulting in the identification of 4 key genes, namely, LIN7A, BASP1, CEBPA, and EMB (Fig. 2r). This evidence concerns the gene LIN7A and acute myeloid leukemia.